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Zopiclone

What is zopiclone? Zopiclone is a psychotropic drug of sedative and hypnotic action. Zopiclone brand name is also Somnol.

Pharmacological effect

Cyclopyrrolone derivative. It is imbued with anticonvulsant, tranquilizing, sedative, muscle relaxant, hypnotic effect. Efficacy of the drug directly influence due to Zopiclone action on CNS receptors, belonging to a macromolecular complex GABA, and also because the modulation of opening chloride ion channels. Zopiclone reduces the frequency of awakenings and sleep (nocturnal and early), significantly increases the duration of sleep, helping to improve the quality of sleep and awakening.

Indications

The main use of the drug Zopiclone:

  • primary sleep disturbances: trouble falling asleep, frequent nocturnal awakening, early awakening (lack of sleep), transient and situational insomnia, chronic insomnia;
  • secondary sleep disorders during mental disorders;
  • asthma, accompanied by early morning and nocturnal seizures (complex therapy at the same time with taking Theophylline).

Contraindications

The drug Zopiclone has such contraindications:

  • sleep apnea syndrome, observed during sleep;
  • acute and severe chronic renal and hepatic failure;
  • severe gravis;
  • severe respiratory failure;
  • hypersensitivity;
  • glucose-galactose malabsorption;
  • lack of Lapp- lactase ;
  • galactose intolerance of inherent nature;
  • pregnancy;
  • lactation period;
  • up to 18 children.

It should be take with care to persons with medical, drug or alcohol addiction in history, as well as the patients who take alcohol and other psychoactive drugs because of the increased risk of abuse or dependence.

Zopiclone dosage

The efficacy of the drug isn’t dependent on the meal. Zopiclone is taken directly for 30-40 minutes before bedtime with water. You should not exceed the dose.

The individual indications affect on the duration of the treatment, medical control is obligatory.

Recommended dosage:

  • two or three weeks - with situational insomnia;
  • from 2 to 5 days - with situational insomnia;
  • from 2 to 5 days - with transient insomnia;
  • one week, but not more than 4 - in chronic insomnia;
  • Individual adjustment - for night attacks of asthma.

Elementary dosage for people suffering from lung, hepatic, renal insufficiency, and in old age - 3,75mg (1/2 tablet), in the future the dose may be increased if necessary to the usual one (7 mg). You shouldn’t take the drug Zopiclone more than 4 weeks in a row. Repeated reception is allowed to the doctor's testimony from the second medical examination.

Zopiclone side effects

Possible side effects of Zopiclone tablets:

Digestive System:

Often:

  • a metallic or bitter taste in the mouth.

There are possible:

  • nausea;
  • dry mouth;
  • dyspepsia;
  • increase of phosphatase in serum alkaline and / or transaminase activity.

CNS:

Upon awakening:

  • dizziness;
  • drowsiness;
  • depression;
  • headache;
  • incoordination;
  • euphoria;
  • anterograde amnesia;
  • aggressiveness.

Aggressiveness

The paradoxical and mental reactions:

  • confusion;
  • hallucinations;
  • nightmares;
  • behavioral changes (oppressive mood, confusion, irritability, inappropriate behavior, possibly associated with amnesia;
  • libido disorder;
  • somnambulism.

Allergic reactions:

  • angioedema;
  • skin rash;
  • anaphylactic reactions;
  • itchy skin.
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